Cantamar International Introduces 1-MNA to the U.S. Market

As consumer demand for science-backed longevity supplements continues to accelerate, supplement brands are searching for differentiated ingredients that offer meaningful clinical support, strong intellectual property, and compelling consumer benefits.

Cantamar International is pleased to announce a new partnership with Pharmena SA of Poland to introduce 1-MNA (1-Methylnicotinamide) to the U.S. nutraceutical market.

This innovative ingredient represents one of the most exciting opportunities in healthy aging, cardiovascular wellness, cellular energy, and exercise performance. With a growing body of published research, 1-MNA offers supplement companies the opportunity to launch truly differentiated products in one of the fastest-growing categories in the nutritional supplement industry.

What is 1-MNA?

1-Methylnicotinamide (1-MNA) is a naturally occurring metabolite of niacin (Vitamin B3) produced within the body through normal cellular metabolism.

For many years it was believed to be biologically inactive. Today, scientific research has demonstrated that 1-MNA functions as an important signaling molecule involved in numerous pathways associated with healthy aging and metabolic health.

Unlike traditional niacin supplements, 1-MNA delivers its benefits without the uncomfortable flushing commonly associated with high-dose niacin.

Clinically Studied Benefits of 1-MNA

Published research has identified multiple areas where 1-MNA may support healthy aging and long-term wellness:

• Healthy Aging & Longevity — Science-backed support for long-term vitality.
• Cardiovascular Health — Improved endothelial function and healthy circulation.
• Nitric Oxide Production — Supports vascular protection and blood flow.
• Cellular Energy & Mitochondrial Support — Fuels healthy cellular function.
• Physical Performance & Recovery — Reduces fatigue and supports exercise recovery.
• Healthy Inflammatory Balance — Supports the body’s natural response.
• Metabolic & Liver Health — Supports key metabolic pathways.
• Cognitive Health — Emerging support for brain performance.
• Skeletal Muscle Function — Supports healthy muscle integrity with aging.

Why Supplement Brands Are Paying Attention

Today’s consumers increasingly understand longevity science. Interest has expanded beyond NAD+, NMN, nicotinamide riboside (NR), spermidine, fisetin, and urolithin A toward ingredients with multiple clinically studied mechanisms of action.

1-MNA complements many of today’s leading longevity ingredients by supporting:

• Cellular Resilience — Promotes healthy cellular aging pathways.
• Vascular Function — Activates prostacyclin and nitric oxide signaling.
• Mitochondrial Efficiency — Supports energy production at the cellular level.
• Exercise Performance & Recovery — Ideal for active aging formulations.
• Healthy Aging Pathways — Broad applicability across longevity categories.

Suggested Daily Dosage

Current human studies have commonly evaluated daily intakes across the following range:

Actual formulation levels should be determined based on intended product positioning, regulatory considerations, and supporting scientific evidence.

Ideal Delivery Formats

One of the major advantages of partnering with Cantamar International is the ability to formulate 1-MNA into multiple premium delivery systems:

Formulation Opportunities

1-MNA pairs well with many clinically studied ingredients to create powerful, differentiated formulations:

Why Partner with Cantamar International?

Cantamar International specializes in helping supplement companies commercialize innovative ingredients before they become mainstream. Our full-service capabilities include:

• Ingredient Sourcing & Exclusive Partnerships — First-mover access to emerging ingredients.
• Product Concept & Formulation Development — From idea to finished formula.
• Clinical Positioning & Regulatory Guidance — Science-backed go-to-market support.
• Contract Manufacturing — cGMP-certified domestic production.
• Private Label & Custom Development — Premium delivery technologies across all formats.

The Future of Longevity Supplement Innovation

The healthy aging market continues to expand as consumers seek evidence-based ingredients that support vitality throughout life. 1-MNA represents an exciting addition to the next generation of longevity ingredients — combining strong scientific interest with multiple applications across cardiovascular health, exercise performance, mitochondrial support, and healthy aging.

Through its partnership with Pharmena SA, Cantamar International is proud to make this innovative ingredient available to U.S. supplement brands seeking meaningful differentiation in an increasingly competitive marketplace.